{"id":1488,"date":"2025-04-29T15:46:32","date_gmt":"2025-04-29T13:46:32","guid":{"rendered":"https:\/\/www.physiologie2.med.fau.de\/?page_id=1488"},"modified":"2026-04-15T11:46:20","modified_gmt":"2026-04-15T09:46:20","slug":"forschung_tv","status":"publish","type":"page","link":"https:\/\/www.physiologie2.med.fau.de\/en\/forschung_tv\/","title":{"rendered":"Lab Prof. Volk"},"content":{"rendered":"\n
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Lab Prof. Volk<\/h1>\n\n\n

The Chair of Cardiovascular Physiology conducts research into the cellular mechanisms underlying cardiac arrhythmias and heart failure. The focus is on cardiac ion channels and their role in cardiac remodeling, a process that impairs electrical excitation and contractile force. Using modern methods such as the patch-clamp technique and high-resolution microscopy, fundamental processes of electromechanical coupling are investigated. The goal is to develop new approaches for the diagnosis, prevention, and treatment of heart disease.
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Cardiac ion channels<\/a><\/h1>\n\n\n\n

The research focus of the Professorship of Cardiovascular Physiology is the study of the pathophysiology of cardiac arrhythmia and heart failure. Heart failure leads to functional and structural alterations at the macroscopic as well as the microscopic and the molecular level, a process called remodeling. Cardiac remodeling during heart failure alters the electromechanical function of the heart, for example by altering the expression of ion channels that control cardiac excitation and repolarization, which increases the risk for cardiac arrhythmia including sudden death. Structural alterations in heart failure, such as an increase in connective tissue (fibrosis) or an alteration of the myocyte architecture, can decrease cardiac contractility and worsen heart failure. Our primary goal is to further understand the molecular mechanisms that underlie remodeling of the heart. This might lead to new diagnostic, therapeutic, or preventive strategies.<\/p>\n\n\n\n

Cardiac ion channels<\/h2>\n\n\n\n
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