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Foto: Uni-Klinikum Erlangen
Neues Hörsaalzentrum

Foto: Uni-Klinikum Erlangen
Internistisches Zentrum (INZ)

Program

ESAC Symposium 2018 on Aldosterone and the Mineralocorticoid Receptor

Symposium venue: Neues Hörsaalzentrum, Ulmenweg 18, 91054 Erlangen

 

 

 

Friday, 7 December 2018

 

 

13:00-13:50 Registration
13:50-14:00 Welcome
14:00-15:30 Session I – Aldosterone Synthesis: physiology, pathophysiology and diseases
Chairs:
Maria-Christina Zennaro (Paris, France)
Eleanor Davies (Glasgow, Scotland, UK)
14:00-14.30 Overview of aldosterone-related genetic syndromes and recent advances
Maria-Christina Zennaro (Paris, France)
14:30-14:45 Sex-specific role of retinoic acid receptor α signaling in adrenal cortex morphology and functional zonation
Rami M. El Zein (Paris, France)
14:45-15:00 Cellular, molecular and genetic heterogeneity in adrenals with aldosterone producing adenoma
Kelly De Sousa (Paris, France)
15:00-15:30 Personalized diagnosis of primary aldosteronism
Teresa M Seccia (Padova, Italy)
15:30-16:00 Coffee
16:00-17:15 Session II – (Patho-)physiological roles of aldosterone and mineralocorticoid receptor (MR) in the kidney and in novel target tissues
Chairs:
Edith Hummler (Lausanne, Switzerland)
Richard Warth (Regensburg, Germany)
16:00-16.30 Aldosterone and renal potassium secretion
Johannes Loffing (Zürich, Switzerland)
16:30-16:45 Complicated receptors in the collecting duct: regulation of ENaC-mediated Na+ transport by corticosteroids
Morag K. Mansley (Edinburgh, UK)
16:45-17:00 Aldosterone-independent ENaC activity in the early part of the aldosterone-sensitive distal nephron critically depends on the presence of MR
Viatcheslav Nesterov (Erlangen, Germany)
17:00-17:15 Metabolic effects of the novel non-steroidal MR antagonist Finerenone in adipose tissue and skeletal muscle in a model of diet-induced obesity
Alessandra Feraco (Rome, Italy)
17:15-18:00 Key note lecture
Chair: Christoph Korbmacher (Erlangen/Germany)
Mechanisms of ENaC regulation by aldosterone in the kidney
Lawrence G. Palmer (New York, USA)
18:00 Transfer from meeting venue to Quality Hotel Erlangen
19:00 Transfer from Quality Hotel Erlangen to Marloffstein
19:30 Dinner at “Gasthof Alter Brunnen” in Marloffstein
23:30 Transfer from Marloffstein to Quality Hotel Erlangen

Foto: Uni-Klinikum Erlangen
Piazza Neues Hörsaalzentrum

Saturday, 8 December 2018

 

 

8:30 Transfer from Quality Hotel Erlangen to meeting venue
09.00-10:15 Session III – (Patho-)physiological roles of aldosterone and MR in the cardiovas-cular system
Chairs:
Jean-Pierre Benitah (Paris, France)
Tilmann Volk (Erlangen, Germany)
09:00-09:30 Impact of MR in vascular cells on gene expression and function
Achim Lother(Freiburg, Germany)
09:30-09:45 Finerenone improves the cardiovascular benefits after a return to a normal diet in the mouse model of high-fat diet-induced obesity
Marie Pieronne-Deperrois (Rouen, France)
09:45-10:00 The mineralocorticoid receptor induces adipose tissue senescence and mitochochondrial dysfunction leading to vascular dysfunction in obesity
Clara Lefranc (Paris, France)
10:00-10:15 Aldosterone effects in cardiac fibroblasts
Natalia López-Andrés (Pamplona, Spain)
10:15-10:45 Coffee
10:45-12:15 Session IV – MR structure, function and signaling
Chairs:
Frédéric Jaisser (Paris, France)
Michael Gekle (Halle, Germany)
10:45-11:15 Modulation of mineralocorticoid receptor signaling
Claudia Großmann (Halle, Germany)
11:15-11:30 MicroRNA 324-5p inhibits renal response to aldosterone by posttranscriptional control of mineralocorticoid receptor expression
Thi-An Vu (Paris, France)
11:30-11:45 NGAL: a new regulator of blood pressure?
Lionel Lattenist (Paris, France)
11:45-12:00 Eplerenone prevents decompensation of liver cirrhosis in male Wistar rats
Barbara Schreier (Halle, Germany)
12:15-14:00 Lunch & Posters*
14:00-15:15 Session V – Translational perspectives and therapeutic innovations
Chairs:
Johann Bauersachs (Hannover, Germany)
Peter Kolkhof (Wuppertal, Germany)
14:00-14:15 Cutaneous wound healing in diabetic mice is improved by topical mineralocorticoid receptor blockade
Van Tuan Nguyen (Paris, France)
14:15-14:30 Mineralocorticoid receptor pathway as a novel therapeutic target for neovascular age-related macular degeneration
Min Zhao (Paris, France)
14:30-14:45 Mineralocorticoid receptor antagonism prevents the acute and chronic effects of ischemic AKI in the Large White pig
Frédéric Jaisser (Paris, France)
14:45-15:15 Diabetic kidney disease and novel MR antagonists
Hermann Haller (Hannover, Germany)
15:15-15:20 Future of ESAC – Closing remarks
Frédéric Jaisser (Paris, France)
Johann Bauersachs (Hannover, Germany)

*All posters will be displayed throughout the meeting and can be visited during the breaks in the foyer of the conference venue.

There will be a dedicated poster session during the lunch break on Saturday (12:15-14:00).

Poster presenters will be asked to be at their posters in particular between 13:00 and 14:00 to answer potential questions of poster reviewers.

There will be two poster groups with thematically related topics. For each poster group we have nominated two poster reviewers whose task is to select one poster from their poster group for a poster prize (200 €).

  • P1 – Jörg D. Schulzke: Intestinal absorption via the epithelial sodium channel (ENaC) is disturbed by interleukin-13 in Campylobacter jejuni infection
  • P2 – Marko Bertog: Lithocholic acid has a sustained stimulatory effect on the epithelial sodium channel (ENaC) in mouse late distal colon
  • P3 – Robert Rauh: A mutation in the α-subunit of the human epithelial sodium channel (ENaC) increases channel membrane expression by reducing the inhibitory effect of Nedd4-2
  • P4 – Benedikt Fels: EnNaC dependent endothelial stiffness is mediated via the RhoA/Rac1 axis and NEDD4-2-regulated internalization
  • P5 – Sachin Sharma: Expression of the epithelial sodium channel (ENaC) and CFTR in the mammalian testicular parenchyma and epididymal epithelia
  • P6 -Alexei Diakov:  Serum- and glucocorticoid-regulated kinase type 1 (SGK1) differently regulates the human epithelial sodium channel (ENaC) in its αβγ and δβγ subunit configuration
  • P7 – Alexandr V. Ilyaskin: Proteolytic activation of the epithelial sodium channel (ENaC) by heterologous co-expression of catalytically inactive prostasin (CAP1) involves endogenous protease activity in Xenopus laevis oocytes
  • P8 – Adrienne M. Assmus: mCCDcl1 cells show Plasticity Consistent with the Ability to Transition between Principal and Intercalated Cells
  • P9 – Helga Vitzthum: High chloride induces aldosterone resistance in the distal nephron
  • P10 – Mads Sørensen: Potassium is sensed locally in the kidney tubules to activate ENaC and promote its own excretion
  • P11 – Jessica R Ivy: Corticosterone activates the thiazide-sensitive NaCl transporter through the glucocorticoid receptor
  • P12 – Ruhs S.: Modulation of transcriptional mineralocorticoid receptor activity by caseinkinase 2
  • P14 – Griesler B.: Casein kinase 1, a potential regulator of the mineralocorticoid receptor

  • P15 – Benjamin Bonnard: Neutrophil Gelatinase-Associated Lipocalin from immune cells involved in renal damages induced by mineralocorticoid excess.
  • 16 – Hannah M Costello: Impairment of pressure natriuresis in a mouse model of ACTH-dependent Cushing Syndrome
  • P17 – Roberto Palacios-Ramirez: Mineralocorticoid receptor antagonism attenuates the metabolic impact observed in mice undergoing 5/6 nephrectomy
  • P18 -Jaime Ibarrola: A new role for aldosterone/mineralocorticoid receptor pathway in mitral valve prolapse
  • P19 – Lisa Deng: Cell type-specific analysis of cardiac endothelial cell transcription and mineralocorticoid receptor function during pressure overload
  • P20 – Jessica Kowalski: Mineralocorticoid receptor antagonism improves experimental pulmonary hypertension and right ventricular failure
  • P21 – Ankita Garg: High-throughput functional screen identifies miR-181a as a novel regulator of Aldosterone-Mineralocorticoid receptor pathway
  • P22 – Christoph Kopp: Detection of Na+ stores in the myocardium and skeletal muscle of DOCA treated mice using 23Na-MRI
  • P23 – Dominik Fiegle: Glucocorticoid Receptor Activation Prevents T-System Loss andUpregulates LC3B in Cultured Rat Cardiomyocytes
  • P24 – Paul-Emmanuel Vanderriele: Salt-sensitive hypertension in a new rat model for primary generalized glucocorticoid resistance
  • P25 – Audrey H Soria: Role of rarα in adrenal cortex morphology and functional zonation in female mice
  • P26 – Selene Prisco: The parathyroid-adrenal gland crosstalk
  • P27 – Patrick Prunet: The in vivo targeted mutation of the mineralocorticoid and glucocorticoid receptors in zebrafish (Danio rerio) provides evidence that both receptors have distinct and redundant effects on female reproduction
  • P28 – Jérémie Canonica: Central serous chorioretinopathy and the identification of newmineralocorticoid molecular targets in retinal pigment epithelium cells